My rough notes at TEDxBoston — they’re worth taking a look at.
-Cardiovascular health is the single most important predictor of longevity…Keeping your cholesterol low is important how…don’t forget about your heart health while you are looking for other longevity solutions…
-Getting a periodic EKG can help determine your age…this is the best way to observe chronic stress…check your blood pressure, as you age, your arteries stiffen which raises your blood pressure…
-We should not be obsessed with increasing our lifespan, but more focused on our healthspan.
-What is the next version of C risper
-Look at Verve
-Eventually, we will have a digital twin that will help us understand what is going on inside of our bodies.
-Our voice, or the sound of our voice, will become a health biomarker
-Website/apps to consider:…digital.health…virta health…jivi.ai
Satchin Panda, PhD (circadian rhythm) https://www.mycircadianclock.org/
-The best way to build longevity is one day at a time…it’s already built into our DNA…this means keeping our circadian rhythm in synch.
-Practice these 3 things:
-LIGHT…day is for performance (get into the daylight as early as possible and make sure to get at least an hour of natural sunlight daily – get out even if it’s a could day), night is for repair 9turn the lights down in the evening and avoid white light or blue light as much as possible – this isn’t just the lights in your house, it’s the light from the screen of your phone as well)… melanopsin = a blue light sensor in our eyes…these are activated by bright daylight, synchronizes the brain clock, raises alertness, reduces depression…BRIGHT SCREENS AT NIGHT DISRUPT THIS…Lighting Revolution
-FOOD (when to eat or not eat our food) fuel vs repair…eat within 9-10 hours (thisf is intermittent fasting, and gives you a bit more time)…the point is to fuel your body during the day, and leave plenty of time for your body to spend time repairing itself, not digesting food
-EXERCISE…sweet spot is late afternoon…this controls your blood glucose level…while many of us want to work out first thing in the morning, our bodies are better prepared for this in the afternoon…this also has the benefit of relaxing us at the end of the day…just don’t do it at night or the reverse will happen.
====> When you do the three things above, sleep takes care of itself
Concept of CHRONOMEDICINE
Do not eat for at least an hour before you wake up
That starts your eating window of 8/9 hours
Get one hour of daylight
No bright light or calories 2/3 hours before bedtime
Matt Kaeberlein https://www.optispan.life/…. Healthspan medicine..rigorous biomarkers..set of medications that help people from getting sick…
-Caloric restriction discussion
-Rapamycin is a drug that helps increase lifespan
-Epigenetic reprogramming.
-NMN does not increase longevity in mice
Aging has not been reversed not even Brian Johnson
Aging is a modifiable biological process
Mariya Filipova – The Convergence Cure
-Periodontal disease causes many diseases
-Medically guided food will be the next thing.
Stephen Thorne – Silvia Science. PDS health.
-Inflammation is a big issue…chronic inflammation is the silent killer…as we age bad bacteria in our mouths increases…
-Bad bacteria in your mouth increases chance of pancreatic cancer by 3x
Thirdspan
-How fully we flourish while we increase lifespan and healthspan
-Pursue joy everyday
“The price of anything is the amount of life you exchange for it” Thoreau
Vivek Natarajan – Google Deep Mind
-The intelligence that they are using to find new healthcare solutions is a bit alien ( this was meant to just be a comment on how they go about their research is very different)
Jackie Iverson – how to Cure a Hangover – alcohol – INFLAMAGING
-Inflammation is the thread that determines how we age…it’s like the hangover that never goes away…low grade inflammation
-4 drivers of inflamaging…genetics, behavior, environment, age itself
-The gut micro biome becomes disgregulated when alcohol becomes present…other longevity people have said to me that no alcohol is best, but a glass of wine every other day is ok…my experience is that more than even two glasses of wine every day is too much for me
-IL-6, CRP, TNF-alpha…these are biomarkers…..
NF-KB…A group of proteins that help control many functions in a cell, including cell growth and survival. These proteins also control the body’s immune and inflammatory responses. NF-kB may be overactive or found in higher than normal amounts in some types of cancer cells. This may lead to cancer cell growth.
-Before drinking
Aleve 220 mg. Add Allegra 60mg immediate release. Take one each before drinking…..
Edmond Douglass- robotics
-Scale with dexterity
AI is a force multiplier…what ever it touches, it amplifies.
Manolis Kellis – he has a company that can use AI to understand chemical structure, genome structure through rapid synthesis…
Stephanie Tillenius Vida Health – Healthspan is Human Freedom
-Data can re-write your story…we call all optimize our healthspan…
-“Your genes load the gun, your lifestyle pulls the trigger.”
-GLP-1’s are good.
